वेबसाइट:कृपया प्रतीक्षा करें... बादल फ्लेरसामग्री
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AdvancedSearch SectionSpecialIssueVolumeIssueNumberPe LogicalOperatorOperatorANDORSearchTextSearchTypeAllfieldsTitleAbstractKeywordsAuthorsAffiliationsDoiFullTextReferences add_circle_outlineremove_circle_outline SensorsHardSyDR:ABenchmarkingEnvironmentforGNSSAlgorithmsMicromachinesAReviewonMachiningSiCp/AlCompositeMaterialsCancersTheRoleofMacrophesinSarcomaTumorMicroenvironmentandTreatmentMathematicsHom-LieSuperalgebrasinCharacteristic2RecentArticles 10pes,356KiB OpenAccessArticleDevelopmentofaTargetedNGSAssayfortheDetectionofRespiratoryPathogensincludingSARS-CoV-2inFelinesbyJobinJ.Kattoor,MothomangMlalazi-Oyinloye,SarahM.NemserandRebeccaP.WilkesPathogens2024,13(4),335;doi.org/10.3390/pathogens(registering DOI)-17Apr2024AbstractAcuterespiratorydiseasesinfelinescanbeattributedtoadiverserangeofpathogens.Therecentemergenceofnovelviruses,particularlySARS-CoV-2anditsvariants,hasalsobeenassociatedwithrespiratoryailmentsincatsandotherpets,underscoringtheneedforahighly[...]Readmore.Acuterespiratorydiseasesinfelinescanbeattributedtoadiverserangeofpathogens.Therecentemergenceofnovelviruses,particularlySARS-CoV-2anditsvariants,hasalsobeenassociatedwithrespiratoryailmentsincatsandotherpets,underscoringtheneedforahighlysensitivedinosticassaycapableofconcurrentlydetectingmultiplerespiratorypathogens.Inthisstudy,wedevelopedatargetednextgenerationsequencingpanelusingIonTorrentAmpliseqtechnologytodetectmultiplerespiratorypathogens,includingrecentSARS-CoV-2variantsandFelineherpesvirus-1,Felinecalicivirus,Bordetellabronchiseptica,Mycoplasmopsis(previouslyMycoplasma)felis,andChlamydiafelis.APCRamplification-basedlibrarypreparation,employingprimersdesignedforpathogentargetregions,wassynthesizedanddividedintotwopools,followedbysequencingandassemblytoarepertoireoftargetpathogengenomes.AnalyticalsensitivitywasassessedbasedonCtvaluesfromreal-timePCRforthecorrespondingpathogens,indicatinganequivalentdetectionlimit.MostofthepathogensunderstudywerepositivelyidentifiedtoalimitofapproximatelyCt36,whereasforFelineherpesvirus-1andSARS-CoV-2,positivereadswereobservedinsampleswithaCtof37.Basedonalimitednumberofsamples,thedinosticsensitivityvaluesfortheSARS-CoV-2,Felineherpesvirus-1,andM.felissampleswere100%withnofalsenegativeresults.ThedinosticspecificityofSARS-CoV-2,Felineherpesvirus-1,Felinecalicivirus,andC.feliswere100%.Importantly,noneofthetargetprimersexhibitednon-specificamplification,ensuringtheabsenceoffalsepositiveresultsforotherpathogenswithinthestudy.Additionally,theassay’sspecificitywasvalidatedbycross-referencingtherawsequencingdatawithestablisheddatabaseslikeBLAST,affirmingthehighspecificityofthetargetedNext-GenerationSequencing(tNGS)assay.Variationsinthesequencingreadsofdifferentpathogenswereobservedwhensubjectedtodiverseextractionmethods.Rigorousassessmentoftheassay’sreliabilityinvolvedreproducibilityacrosstestingpersonnelandrepeatedruns.Thedevelopedassay’sclinicalapplicabilitywastestedusingsamplessubmittedtothedinosticlaboratoryfromcatsheltersandsuspectedcases.Thedevelopedtargetednext-generationsequencingmethodologyempowersthedetectionofmultiplerespiratorypathogensmanifestingsimilarclinicalsymptomswhileofferingconfirmationofresultsthroughgenomesequencing.Fullarticle(ThisarticlebelongstotheSpecialIssueDinosticsofAnimalViralInfectiousDiseases)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,63KiB)22pes,4938KiB OpenAccessArticleFunctionalandMolecularAnalysisofHumanOsteoarthriticChondrocytesTreatedwithBoneMarrow-DerivedMSC-EVsbyAnnachiaraScalzone,ClaraSanjurjo-Rodríguez,RolandoBerlinguer-Palmini,AnneM.Dickinson,ElenaJones,Xiao-NongWangandRachelE.CrosslandBioengineering2024,11(4),388;doi.org/10.3390/bioengineering(registering DOI)-17Apr2024AbstractOsteoarthritis(OA)isadegenerativejointdisease,causingimpairedmobility.Therearecurrentlynoeffectivetherapiesotherthanpalliativetreatment.Mesenchymalstromalcells(MSCs)andtheirsecretedextracellularvesicles(MSC-EVs)heshownpromiseinattenuatingOAprogression,promotingchondralregeneration,andmodulatingjoint[...]Readmore.Osteoarthritis(OA)isadegenerativejointdisease,causingimpairedmobility.Therearecurrentlynoeffectivetherapiesotherthanpalliativetreatment.Mesenchymalstromalcells(MSCs)andtheirsecretedextracellularvesicles(MSC-EVs)heshownpromiseinattenuatingOAprogression,promotingchondralregeneration,andmodulatingjointinflammation.However,theprecisemolecularmechanismofactiondrivingtheirbeneficialeffectshasnotbeenfullyelucidated.Inthisstudy,weanalyzedMSC-EV-treatedhumanOAchondrocytes(OACs)toassessviability,proliferation,migration,cytokineandcatabolicproteinexpression,andmicroRNAandmRNAprofiles.WeobservedthatMSC-EV-treatedOACsdisplayedincreasedmetabolicactivity,proliferation,andmigrationcomparedtothecontrols.Theyproduceddecreasedproinflammatory(Il-8andIFN-γ)andincreasedanti-inflammatory(IL-13)cytokines,andlowerlevelsofMMP13proteincoupledwithreducedexpressionofMMP13mRNA,aswellasnegativemicroRNAregulatorsofchondrogenesis(miR-145-5pandmiR-21-5p).In3Dmodels,MSC-EV-treatedOACsexhibitedenhancedchondrogenesis-promotingfeatures(elevatedsG,ACAN,andgrecan).MSC-EVtreatmentalsoreversedthepathologicalimpactofIL-1βonchondrogenicgeneexpressionandextracellularmatrixcomponent(ECM)production.Finally,MSC-EV-treatedOACsdemonstratedtheenhancedexpressionofgenesassociatedwithcartilefunction,collenbiosynthesis,andECMorganizationandexhibitedasignatureof24differentiallyexpressedmicroRNAs,associatedwithchondrogenesis-associatedpathwaysandECMinteractions.Inconclusion,ourdataprovidenewinsightsonthepotentialmechanismofactionofMSC-EVsasatreatmentoptionforearly-steOA,includingtranscriptomicanalysisofMSC-EV-treatedOA,whichmaypethewayformoretargetednoveltherapeutics.Fullarticle(ThisarticlebelongstotheSectionRegenerativeEngineering)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7attachmentSupplementarymaterial:SupplementaryFile1(ZIP,68KiB)18pes,3912KiB OpenAccessArticleNLRX1InhibitsLPS-InducedMicroglialDeathviaInducingp62-DependentHO-1Expression,InhibitingMLKLandActivatingPARP-1byYu-LingHuang,Duen-YiHuang,VladlenKlochkov,Chi-MingChan,Yuan-ShenChenandWan-WanLinAntioxidants2024,13(4),481;doi.org/10.3390/antiox(registering DOI)-17Apr2024AbstractTheactivationofmicrogliaandtheproductionofcytokinesarekeyfactorscontributingtoprogressiveneurodegeneration.Despitethewell-recognizedकृपया प्रतीक्षा करें... बादल फ्लेरneuronalprogrammedcelldeathregulatedbymicroglialactivation,thedeathofmicrogliathemselvesislessinvestigated.Nucleotide-bindingoligomerizationdomain,leucine-richrepeat-containingX1(NLRX1)functions[...]Readmore.Theactivationofmicrogliaandtheproductionofcytokinesarekeyfactorscontributingtoprogressiveneurodegeneration.Despitethewell-recognizedneuronalprogrammedcelldeathregulatedbymicroglialactivation,thedeathofmicrogliathemselvesislessinvestigated.Nucleotide-bindingoligomerizationdomain,leucine-richrepeat-containingX1(NLRX1)functionsasascaffoldingproteinandisinvolvedinvariouscentralnervoussystemdiseases.Inthisstudy,weusedtheSM826microglialcellstounderstandtheroleofNLRX1inlipopolysaccharide(LPS)-inducedcelldeath.WefoundLPS-inducedcelldeathisblockedbynecrostatin-1andzVAD.Meanwhile,LPScanactivatepoly(ADP-ribose)polymerase-1(PARP-1)toreduceDNAdameandinducehemeoxygenase(HO)-1expressiontocounteractcelldeath.NLRX1silencingandPARP-1inhibitionbyolaparibenhanceLPS-inducedSM826microglialcelldeathinanadditivemanner.LessPARylationandhigherDNAdameareobservedinNLRX1-silencingcells.Moreover,LPS-inducedHO-1geneandproteinexpressionthroughthep62-Keap1-Nrf2axisareattenuatedbyNLRX1silencing.Inaddition,theNrf2-mediatedpositivefeedbackregulationofp62isaccordinglyreducedbyNLRX1silencing.Ofnote,NLRX1silencingdoesnotaffectLPS-inducedcellularreactiveoxygenspecies(ROS)productionbutincreasesmixedlineekinasedomain-likepseudokinase(MLKL)activationandcellnecroptosis.Inaddition,NLRX1silencingblocksbafilomycinA1-inducedPARP-1activation.Takentogether,forthefirsttime,wedemonstratetheroleofNLRX1inprotectingmicrogliafromLPS-inducedcelldeath.TheunderlyingprotectivemechanismsofNLRX1includeupregulatingLPS-inducedHO-1expressionviaNrf2-dependentp62expressionanddownstreamKeap1-Nrf2axis,mediatingPARP-1activationforDNArepairviaROS-andautophy-independentpathway,andreducingMLKLactivation.Fullarticle(ThisarticlebelongstotheSpecialIssueOxidativeStressandNrf2-MediatedCellularInflammation)9658;9660;ShowFiguresGraphicalabstractFigure1---Figure2---Figure3---Figure4---Figure5---Figure6---Figure7attachmentSupplementarymaterial:SupplementaryFile1(ZIP,1501KiB)24pes,919KiB OpenAccessArticleBuildingtheResilienceofMarginalRuralAreasUsingaComplementaryCharacterizationApproach:PossibleBeneficialHealthEffectsandStressToleranceofItalianCommonBean(PhaseolusvulgarisL.)LandracesbyMartinaFalcione,AlessandraRenella,VadymSamukha,MayraColardo,MelissaSimiele,GabriellaStefaniaScippa,MarcoSegattoandDalilaTrupianoDiversity2024,16(4),240;doi.org/10.3390/d(registering DOI)-17Apr2024AbstractCommonbeanlandraces,besidescontributingtothepreservationofthesocialandculturalidentityofthelocalcommunitiesoftheproductionarea,typicallydisplayadaptabilitytoadversero-climaticconditions.Thisadaptedgermplasmisarepositoryofthegenepoolandalsoshowstypical[...]Readmore.Commonbeanlandraces,besidescontributingtothepreservationofthesocialandculturalidentityofthelocalcommunitiesoftheproductionarea,typicallydisplayadaptabilitytoadversero-climaticconditions.Thisadaptedgermplasmisarepositoryofthegenepoolandalsoshowstypicalphytochemicalprofiles,representinganessentialsourceofbioactivecomponents.However,geneticerosionisprogressivelyaffectingthisgeneticmaterial,creatingseriousthreatstoitscultivationinmarginalruralareasanduseasasourceofbiodiversityandbioproducts.Inthepresentwork,acomprehensiveapproachwasusedtocharacterizetheseedmorpho-colorimetrictraits,geneticdiversity,andNMRmetabolomicprofilesofthreeItaliancommonbeanlandraces.Specificphysiologicalandbiochemicalfeatures(antioxidantmolecules,osmolytes,structuralreorganizationofphotosyntheticpigment,etc.),togetherwiththeaccumulationofdistinctivemetabolites,contributetothedescriptionoftheobserveddiversityamongthelandracesintermsofthesaltstressresponseandantiproliferativeabilitiesonintestinalhumancancercells.Thisinformationcouldbeusefulinestablishingtheirvalueintermsofenvironmentaland/orhumanhealth“service”,bothessentialtotranslatinglandracesintocompetitiveproducts,aprerequisiteforenvisioningappropriatestrategiesfortheirconservationandadrivingforcefortherevitalizationofmarginalruralareas.Fullarticle(ThisarticlebelongstotheSpecialIssueAdvancesinCropGeneticDiversity:ChallengesandOpportunities)12pes,1090KiB OpenAccessArticleComparativeBioactiveCompoundsandMineralPropertiesofSouthAfricanandLesothoArtemisiaafra(Jacq.)GenotypesbyMatumeloRafiri,MoosaMahmoodSedibeandGoitsemangMahlomolaHendryDikanePlants2024,13(8),1126;doi.org/10.3390/plants(registering DOI)-17Apr2024AbstractArtemisiaafraisaplantthatgrowsinthenorthern,central,andcoastalregionsofSouthAfrica,aswellasinneighboringcountriessuchasEswatiniandLesotho.Thesephytochemicalscanbeusedasactivecompoundsinplant-basedmedicine.Therefore,itisimportant[...]Readmore.Artemisiaafraisaplantthatgrowsinthenorthern,central,andcoastalregionsofSouthAfrica,aswellasinneighboringcountriessuchasEswatiniandLesotho.Thesephytochemicalscanbeusedasactivecompoundsinplant-basedmedicine.Therefore,itisimportanttodeterminehowplantmineralsandphytochemicals,particularlybioactivecompounds,areaffectedbythegeolocationinwhichtheygrow.ThisstudyaimedtoevaluatethemineralandphytochemicalpropertiesofA.afragenotypesinthesouthernregionsofAfrica.LeafsamplesofA.afragenotypeswerecollectedfromLesotho,inMohale’sHoekandRoma.InSouthAfrica,leafsampleswerecollectedinWepenerandHobhouse,and80plantswererandomlyselectedforphytochemicalandmineralanalyses.Thisstudyrevealsthatphosphorus,calcium,potassium,iron,andzincloadedpositivelytothefirstprincipalcomponent,whilecopperloadedpositivelytothesecondprincipalcomponentwithvariabilitiesof29.95%and21.12%,respectively.Furthermore,boththeMohale’sHoekandHobhousegenotypesexhibitedrelativelyhighlevelsofascorbicacid,phenoliccompounds,flonoids,andtannins.ItisworthnotingthatgenotypesfromRomaandWepenershowedhigherlevelsoffoliarmnesium.Thus,theMohale’sHoekandHobhousegenotypescouldberecommendedfortheirbetterphytochemicalcontents.Fullarticle(ThisarticlebelongstotheSpecialIssueAdvancedResearchonAfricanMedicinalPlants)9658;9660;ShowFiguresFigure1Figure2---Figure324pes,3148KiB OpenAccessArticleSustainabilityEvaluationofResidentialBuildingsBasedontheFootprintFamily:ApplicationtoCaseStudiesinAndalusiabyJaimeSolís-Guzmán,PaulaGarzón-González,PatriciaGonzález-VallejoandMadelynMarreroBuildings2024,14(4),1131;doi.org/10.3390/buildings(registering DOI)-17Apr2024AbstractThecriteriaongreenpublicprocurementoftheEuropeanUnionestablishthattheeconomicbudgetsofbuildingprojectsmustbecomplementedbytheirderivedenvironmentalandsocialcosts.Thesecriteriaarecurrentlybeingadaptedtotherequirementsrelatedtothecirculareconomy,such[...]Readmore.ThecriteriaongreenpublicprocurementoftheEuropeanUnionestablishthattheeconomicbudgetsofbuildingprojectsmustbecomplementedbytheirderivedenvironmentalandsocialcosts.Thesecriteriaarecurrentlybeingadaptedtotherequirementsrelatedtothecirculareconomy,suchastheuseofmethodstoevaluatebuildingsenvironmentally.However,mostmethodsailableintheEuropeanandSpanishmarketsrequirepriortraining,whichmakestheirusedifficult.Thispaperpresentsanevaluationmethod,CEACE,forhousingconstructionbasedonthedeterminationoftheirfootprints(ecological,carbon,andwaterfootprints),alsocalledthefootprintfamily,towhichtheeconomicandsocialevaluationisadded,asisthequantificationoftheconstructionanddemolitionwastegenerated.ThismethodisvalidatedwiththeassessmentoffifteenresidentialbuildingsinAndalusiaandcreatesanindicatorthatwillallowtechnicians,companies,andadministrationstoevaluateprojectsinaccordancewiththecriteriaofgreenpublicprocurement.Themethodissensitivetochangesinthetypeofbuilding,foundationsolution,andundergroundconstruction.Fullarticle(ThisarticlebelongstotheSpecialIssueAdvancesinProjectDevelopmentandConstructionManement)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5attachmentSupplementarymaterial:SupplementaryFile1(ZIP,945KiB)15pes,1394KiB OpenAccessArticleTheRelationbetweenAtmosphericAerosolConcentrationandSARS-CoV-2Variants’InfectionandMortalityRatesintheUnitedStates:ARemote-SensingPerspectivebyYasinElshorbany,SarahMixson,LailaMarcumandJasonL.SalemiSustainability2024,16(8),3381;doi.org/10.3390/su(registering DOI)-17Apr2024AbstractNumerousstudieshehighlightedthehealthbenefitsassociatedwithreducingaerosolparticlesandotherpollutants.RecentstudiesheshownapositivecorrelationbetweenexposuretoaerosolparticlesandCOVID-19cases.Inthisstudy,weinvestigatetherelationshipbetweenaerosolparticleconcentrationandCOVID-19[...]Readmore.Numerousstudieshehighlightedthehealthbenefitsassociatedwithreducingaerosolparticlesandotherpollutants.RecentstudiesheshownapositivecorrelationbetweenexposuretoaerosolparticlesandCOVID-19cases.Inthisstudy,weinvestigatetherelationshipbetweenaerosolparticleconcentrationandCOVID-19variants’infectionandmortalityrates.Remote-sensingdataonaerosolopticaldepth(AOD),asurrogateforatmosphericaerosollevels,werecollectedandanalyzedinthreeregionswithinthestatesofCalifornia,Illinois,andNorthandSouthCarolina.TheseregionswereselectedtoreflectthevariabilityinaerosolconcentrationandanomaliesduringtheCOVID-19period(2020–2022)comparedtoareferenceperiod(2010–2019).WefoundconsistentpositivelinearcorrelationsacrossmostregionsbetweenCOVID-19mortalityratesandAODlevelsbelow0.2.Thesecorrelationswerefoundtobeindependentofthechangeinaerosollevelsrelativetothereferenceperiod.InNorthandSouthCarolina,theDeltavariantwasassociatedwithnotonlyahighmortalityratebutalsoasteeperincreaseinmortalityrateperAODof39.6±1.5(R2=0.87)comparedtoAlphaat10.5±0.3(R2=0.85).However,duetothelowermortalityrateoftheDeltavariantcomparedtotheAlphavariantinIllinois,theDeltavarianthasalowercorrelationslopeof28.3±1(R2=0.94)comparedtotheAlphavariantat52.1±1.8(R2=0.78).NocorrelationbetweenmortalityrateandAODwasobservedfortheOmicronvariantsinanyoftheinvestigatedcountiesexceptinCaliforniawhereaweakpositivecorrelationwasevident.OurfindingsestablishacompellinglinkbetweenaerosolconcentrationsandSARS-CoV-2infectionandmortality.Ourresultsunderscoretheurgentneedforfurtherresearchtoelucidatetheunderlyingmechanismsandbroaderimplications,leadingtomoresustainablesolutionstocurbtheairbornetransmissionofCOVID-19virusesandotherviralinfectionsingeneral.Fullarticle(ThisarticlebelongstotheSpecialIssueEnvironmentalPollutionandImpactsonHumanHealth)26pes,3028KiB OpenAccessArticleAComprehensiveEvaluationofResilienceinAbandonedOpen-PitMineSlopesBasedonaTwo-DimensionalCloudModelwithCombinationWeightingbyLiangxingJin,PingtingLiu,WenbingYaoandJunjieWeiMathematics2024,12(8),1213;doi.org/10.3390/math(registering DOI)-17Apr2024AbstractThestabilityofabandonedopen-pitmineslopesandtheirecologicalenvironmentarethreatenedowingtotheirfrile,complicated,anduncertaincharacteristics.Thisstudyestablishesanovelevaluationindicatorsystemforenhancingminedesignandenvironmentalprotectioninsight.Theweightsinthesystemare[...]Readmore.Thestabilityofabandonedopen-pitmineslopesandtheirecologicalenvironmentarethreatenedowingtotheirfrile,complicated,anduncertaincharacteristics.Thisstudyestablishesanovelevaluationindicatorsystemforenhancingminedesignandenvironmentalprotectioninsight.Theweightsinthesystemareassignedusingacombinedmethod,whichconsistsofthegametheory,theintervalanalytichierarchyprocess(IAHP),andtheentropyweightmethod(EWM).TheIAHPisoptimizedbytheimprovedradialmovementoptimal(IRMO)algorithmandthesimulatedannealing(SA)algorithmtoensurecalculationstabilityandefficiency.Meanwhile,atwo-dimensionalcloudmodel(TDCM)isdevelopedtoobtainthesloperesiliencelevelandvisualizetheresult.ThiscomprehensiveevaluationmethodisappliedtothreeabandonedmineslopesintheYellowRiverBasin,andtheresultsdemonstratethatthemethodcanprovidecrucialinsightsforrationalmineslopestabilizationandecologicalrestoration.Fullarticle(ThisarticlebelongstotheTopicPhysicalMonitoringandHealthyControllingofGeotechnicalEngineering)11pes,283KiB OpenAccessArticleStudyofSalmonellaspp.fromCePapersBelongingtoPetBirdsinanArgentineanCanaryBreederChampionshipbyDanteJ.Bueno,FranciscoI.Rodríguez,LucianaC.Machado,MarioA.Soria,FranciscoProcura,SilvanaC.Gómez,TeresaM.Hoffmann,AndreaAlcain,MaríaI.Caffer,JuanD.LatorreandJierO.QuintarAnimals2024,14(8),1207;doi.org/10.3390/ani(registering DOI)-17Apr2024AbstractBirds,includingcanariesandotherbirds,hebecomeincreasinglypopularaspets.Birdfairs,wherebreedersgatherandshowtheirproductioninachampionshipsetting,presentasettingforpossibleSalmonellaspp.contaminationandtransmission.Therefore,thisstudyestimatedtherateofSalmonella[...]Readmore.Birds,includingcanariesandotherbirds,hebecomeincreasinglypopularaspets.Birdfairs,wherebreedersgatherandshowtheirproductioninachampionshipsetting,presentasettingforpossibleSalmonellaspp.contaminationandtransmission.Therefore,thisstudyestimatedtherateofSalmonellaspp.isolationfromcepapers,locatedinthebottomofcesofexoticpetbirds,includingcanaries.CollectedSalmonellaisolateswereusedtodeterminetheantimicrobialresistanceprofileto52antibioticsand17commercialdisinfectants,basedonpureoramixtureofacids,alcohols,aldehydes,alkalis,halogens,peroxygen,andquaternaryammoniumcompounds.Thesamplesconsistedof774cepaperstakeninthe2015Argentineancanarybreederchampionship,poolingthreecepapersintoonesterilesamplingb.OnlyonepoolofthecepaperswaspositiveforSalmonellaspp.(0.4%),whichbelongedtothesamplefromthreefrillcanaryces.TwostrainsofSalmonellaserotypeGlostrupwereisolated,whichwereonlyresistanttosulfonamidesanderythromycinandsensitivetoalkali-basedproductPL301AS.AlthoughtherateofSalmonellaspp.isolationfromcepapersinanArgentineancanarybreederchampionshipislow,itshouldnotbediscountedbecauseSalmonellaser.GlostrupcanbeasourceofhumanSalmonellaoutbreaksandtheyshowhighresistancetodisinfectingproducts.Fullarticle(ThisarticlebelongstotheSectionBirds)16pes,364KiB OpenAccessArticleTheEUInterregProject“ADRINET”:AssessmentofWell-KnownandEmergingPollutantsinSeafoodandTheirPotentialEffectsforFoodSafetybyElisabettaBonerba,FatmiraShehu,AnnamariaPandiscia,PatrizioLorusso,AlessioManfredi,AleksandraHuter,GiuseppinaM.Tantillo,SaraPanseri,MariaNobileandValentinaTerioFoods2024,13(8),1235;doi.org/10.3390/foods(registering DOI)-17Apr2024AbstractAnthropogenicactivitiesleadtothespreadofchemicalsandbiologicalmaterials,includingplasticwaste,toxicmetals,andpharmaceuticals,ofwhichtheimpactontheMediterraneanSeaisofhighconcern.Inthiscontext,theEUInterregItaly-Albania-MontenegroProject“ADRINET(AdriaticNetworkfor[...]Readmore.Anthropogenicactivitiesleadtothespreadofchemicalsandbiologicalmaterials,includingplasticwaste,toxicmetals,andpharmaceuticals,ofwhichtheimpactontheMediterraneanSeaisofhighconcern.Inthiscontext,theEUInterregItaly-Albania-MontenegroProject“ADRINET(AdriaticNetworkforMarineEcosystem)_244”(2018–2020)arises.Itaimstocarryoutbiomonitoringcampaignsinthemaincommercialinterestoffishandcephalopodspecies,suchasSparusaurata, Dicentrarchuslabrax,Sepiaspp.,andLoligospp.sampledinthreedifferentsubregionsoftheMediterraneanSea.Thepresenceofthemainenvironmentalcontaminants,suchascadmium,microplastics,andantibioticswasinvestigatedintheseseafoodsamples.Contaminationbycadmiumandantibioticsintheseafoodinvestigatedinourstudywasnegligible.However,ahighvalueofmicroplasticswasdetectedinthestomachandgutofSparusaurataandDicentrarchuslabrax.Overall,eventhoughthepresenceofmicroplasticsneedstobeinvestigatedbyfurtherstudies,theresultsconfirmedthattheenvironmentalconditionsofthethreebaysinvestigatedbytheADRINETprojectpartners(Italy,Albania,Montenegro)arepositiveandnotaffectedbyintensiveanthropogenicactivity.Fullarticle(ThisarticlebelongstotheSpecialIssueMicrobiologicalQualityandSafetyinAnimalandVegetable-SourcedFood)32pes,1053KiB OpenAccessReviewRecentAdvancesinPathologyofIntrahepaticCholangiocarcinomabyJoonHyukChoiandSwanN.ThungCancers2024,16(8),1537;doi.org/10.3390/cancers(registering DOI)-17Apr2024AbstractIntrahepaticcholangiocarcinoma(ICCA)isamalignantepithelialneoplasmcharacterizedbybiliarydifferentiationwithintheliver.ICCAismolecularlyheterogeneousandexhibitsabroadspectrumofhistopathologicalfeatures.Itisahighlygressivecarcinomawithhighmortalityandpoorsurvivalrates.ICCAsareclassified[...]Readmore.Intrahepaticcholangiocarcinoma(ICCA)isamalignantepithelialneoplasmcharacterizedbybiliarydifferentiationwithintheliver.ICCAismolecularlyheterogeneousandexhibitsabroadspectrumofhistopathologicalfeatures.Itisahighlygressivecarcinomawithhighmortalityandpoorsurvivalrates.ICCAsareclassifiedintotwomainsubtypes:thesmall-ducttypeandlarge-ducttypes.Thesetwotumortypeshedifferentcelloriginsandclinicopathologicalfeatures.ICCAsarecharacterizedbynumerousmolecularalterations,includingmutationsinKRAS,TP53,IDH1/2,ARID1A,BAP1,BRAF,SAMD4,andEGFR,andFGFR2fusion.Twomainmolecularsubtypes—inflammationandproliferation—hebeenproposed.Recentadvancesinhigh-throughputassaysusingnext-generationsequencingheimprovedourunderstandingofICCApathogenesisandmoleculargenetics.ThedinosisofICCAposesasignificantchallengeforpathologistsbecauseofitsvariedmorphologiesandphenotypes.AccuratedinosisofICCAisessentialforeffectivepatientmanementandprognosticdetermination.ThisarticleprovidesanupdatedoverviewofICCApathology,focusingparticularlyonmolecularfeatures,histologicalsubtypes,anddinosticapproaches.Fullarticle(ThisarticlebelongstotheSpecialIssueCurrentEpidemiologic,Dinostic,andTherapeuticAspectsofCholangiocarcinoma(CCA))attachmentSupplementarymaterial:SupplementaryFile1(ZIP,556KiB)18pes,573KiB OpenAccessArticleHealthLiteracyofChildrenandAdolescentswithInflammatoryBowelDisease(IBD)andParentsofIBDPatients—CopingandInformationNeedsbyKalinaKaul,StefanSchumann,CorneliaSander,JanDäbritzandJandeLaffolieChildren2024,11(4),481;doi.org/10.3390/children(registering DOI)-17Apr2024AbstractBackground:Thenumberofchildrenandadolescentswithinflammatoryboweldisease(IBD)isincreasing.Manychronicallyillchildrenandadolescentshelowhealthliteracy.Patientempowerment(PE)enablespositivechangesandcontroloverone’sdiseasethroughspecificactivities,information,andcounseling.TheCEDNA[...]Readmore.Background:Thenumberofchildrenandadolescentswithinflammatoryboweldisease(IBD)isincreasing.Manychronicallyillchildrenandadolescentshelowhealthliteracy.Patientempowerment(PE)enablespositivechangesandcontroloverone’sdiseasethroughspecificactivities,information,andcounseling.TheCEDNA(IBDNeedsAssessment)SurveyaimedtoprovidethenecessarydatatoimprovePEinpediatricIBD(PIBD).Methods:QuestionnairesweredistributedtoadolescentIBDpatientsandparentsofchildrenandadolescentswithIBDthroughoutGermany.Theanswersweregivenanonymously.Basedontheailabledata,asubgroupanalysiswasconductedinrelationtotheeofthepatientsandtheperiodsincedinosis.Fortheparents’responses,thesameegroupswereanalyzedforcomparisonwiththepatients’responses.Results:FromOctober2021toApril2022,2810questionnairesweredistributedand1158questionnaireswerecompleted(n=708parents[61.1%],n=450patients[38.9%]).TheresultsindicatethathealthliteracyinchildrenwithIBDislow.SignificantgapsinknowledgeofimportantIBDtopicswereidentified,andacomparisonofresponsesregardingpreferredmethodsandtimingofobtaininginformationrevealeddifferencesbetweenpatientandparentpreferences.ThegreatestneedforknowledgeonIBDtopicswasfoundinthegroupof16–17-year-oldpatientsontransition(n=214,31.8%)andinthegroupofpatientsdinosed1–2yearsoonthecausesofIBD(n=288,17.4%).Thewillingnesstoseekadvicewasunexpectedlylow.Conclusions:Theanalysisofallfindingsaccordingtothepatient’sestructureanddurationsincedinosiscanbeusedtoenablee-appropriatecommunicationatcertainstesofthedisease.Thistailoredinformationshouldincreasepatients’healthliteracy,improvetheirmanementofthedisease,andreducetheburdenontheirfamilies.Fullarticle(ThisarticlebelongstotheSpecialIssueHealthBehiour,HealthLiteracyandMentalHealthinChildren)9658;9660;ShowFiguresGraphicalabstract20pes,1009KiB OpenAccessArticleStationaryDistributionofStochastice-DependentPopulation–ToxicantModelwithMarkovSwitchingbyYanyanDuandZongWangMathematics2024,12(8),1212;doi.org/10.3390/math(registering DOI)-17Apr2024AbstractThisworkfocusesontheconvergenceofthenumericalinvariantmeasureforastochastice-dependentpopulation–toxicantmodelwithMarkovswitching.ConsideringthatEuler–Maruyama(EM)hastheadvanteoffastcomputationandlowcost,explicitEMwasusedtodiscretizethetimevariable.With[...]Readmore.Thisworkfocusesontheconvergenceofthenumericalinvariantmeasureforastochastice-dependentpopulation–toxicantmodelwithMarkovswitching.ConsideringthatEuler–Maruyama(EM)hastheadvanteoffastcomputationandlowcost,explicitEMwasusedtodiscretizethetimevariable.Withthehelpofthep-thmomentboundednessoftheanalyticalandnumericalsolutionsofthemodel,theexistenceanduniquenessofthecorrespondinginvariantmeasureswereobtained.Undersuitableassumptions,theconclusionthatthenumericalinvariantmeasureconvergestotheinvariantmeasureoftheanalyticsolutionwasprovenbydefiningtheWassersteindistance.Anumericalsimulationwasperformedtoillustratethetheoreticalresults.Fullarticle21pes,1908KiB OpenAccessArticleDDPG-basedConvexProgrammingAlgorithmfortheMidcourseGuidanceTrajectoryofInterceptorbyWan-LiLi,JiongLi,Ji-KunYe,LeiShaoandChi-JunZhouAerospace2024,11(4),314;doi.org/10.3390/aerospace(registering DOI)-17Apr2024AbstractToaddresstheproblemoflowaccuracyandefficiencyintrajectoryplanningalgorithmsforinterceptorsfacingmultipleconstraintsduringthemidcourseguidancephase,animprovedtrajectoryconvexprogrammingmethodbasedonthelateraldistancedomainisproposed.Thisalgorithmcanachievefasttrajectory[...]Readmore.Toaddresstheproblemoflowaccuracyandefficiencyintrajectoryplanningalgorithmsforinterceptorsfacingmultipleconstraintsduringthemidcourseguidancephase,animprovedtrajectoryconvexprogrammingmethodbasedonthelateraldistancedomainisproposed.Thisalgorithmcanachievefasttrajectoryplanning,reducetheapproximationerroroftheplannedtrajectory,andimprovetheaccuracyoftrajectoryguidance.First,theconceptoflateraldistancedomainisproposed,andthemotionmodelofthemidcourseguidancesegmentintheinterceptorisconvertedfromthetimedomaintothelateraldistancedomain.Second,themotionmodelandmultipleconstraintsareconvexlyanddiscretelytransformed,andthediscretetrajectoryconvexmodelisestablishedinthelateraldistancedomain.Third,thedeepreinforcementlearningalgorithmisusedtolearnandtraintheinitialsolutionoftrajectoryconvexprogramming,andahigh-qualityinitialsolutiontrajectoryisobtained.Finally,adynamicadjustmentmethodbasedonthedistributionofapproximatesolutionerrorsisdesignedtoachieveefficientdynamicadjustmentofgridpointsiniterativesolving.Thesimulationexperimentsshowthattheimprovedtrajectoryconvexprogrammingalgorithmproposedinthispapernotonlyimprovestheaccuracyandefficiencyofthealgorithmbutalsohasgoodoptimizationperformance.FullarticleattachmentSupplementarymaterial:SupplementaryFile1(ZIP,2198KiB)13pes,3341KiB OpenAccessArticleFurtherCharacterizationoftheAntiviralTransmembraneProteinMARCH8byTakuyaTada,YanzhaoZhang,DechuanKong,MichikoTanaka,WeitongYao,MasanoriKameoka,TakamasaUeno,HideakiFujitaandKenzoTokunaCells2024,13(8),698;doi.org/10.3390/cells(registering DOI)-17Apr2024AbstractThecellulartransmembraneproteinMARCH8impedestheincorporationofvariousviralenvelopeglycoproteins,suchastheHIV-1envelopeglycoprotein(Env)andvesicularstomatitisvirusG-glycoprotein(VSV-G),intovirionsbydownregulatingthemfromthesurfaceofvirus-producingcells.Thisdownregulationsignificantlyreducestheefficiency[...]Readmore.ThecellulartransmembraneproteinMARCH8impedestheincorporationofvariousviralenvelopeglycoproteins,suchastheHIV-1envelopeglycoprotein(Env)andvesicularstomatitisvirusG-glycoprotein(VSV-G),intovirionsbydownregulatingthemfromthesurfaceofvirus-producingcells.Thisdownregulationsignificantlyreducestheefficiencyofvirusinfection.Inthisstudy,weaimedtofurthercharacterizethishostproteinbyinvestigatingitsspeciesspecificityandthedomainsresponsibleforitsantiviralactivity,aswellasitsabilitytoinhibitcell-to-cellHIV-1infection.WefoundthattheantiviralfunctionofMARCH8iswellconservedintherhesusmacaque,mouse,andbovineversions.TheRING-CHdomainsoftheseversionsarefunctionallyimportantforinhibitingHIV-1EnvandVSV-G-pseudovirusinfection,whereastyrosinemotifsarecrucialfortheformeronly,consistentwithfindingsinhumanMARCH8.ThroughanalysisofchimericproteinsbetweenMARCH8andnon-antiviralMARCH3,wedeterminedthatboththeN-terminalandC-terminalcytoplasmictails,aswellaspresumablytheN-terminaltransmembranedomain,ofMARCH8arecriticalforitsantiviralactivity.Notably,wefoundthatMARCH8isunabletoblockcell-to-cellHIV-1infection,likelyduetoitsinsufficientdownregulationofEnv.Thesefindingsofferfurtherinsightsintounderstandingthebiologyofthisantiviraltransmembraneprotein.Fullarticle(ThisarticlebelongstotheSpecialIssueUntanglingtheCross-TalkbetweenImmuneResponsesandInfection)9658;9660;ShowFiguresFigure1Figure2---Figure338pes,KiB OpenAccessReviewAdvancesinHigh–Speed,High–PowerPhotodiodes:FromFundamentalstoApplicationsbyQingtaoChen,XiupuZhang,MohammadS.SharawiandRamanKashyapAppl.Sci.2024,14(8),3410;doi.org/10.3390/app(registering DOI)-17Apr2024AbstractHigh–speed,high–powerphotodiodesplayakeyroleinwirelesscommunicationsystemsforthegenerationofmillimeterwe(MMW)andterahertz(THz)wesbasedonphotonics–basedtechniques.Uni–treling–photodiode(UTC–PD)isanexcellentcandidate,notonlymeetingtheabove–mentionedrequirementsofbroadband(3GHz~1THz)[...]Readmore.High–speed,high–powerphotodiodesplayakeyroleinwirelesscommunicationsystemsforthegenerationofmillimeterwe(MMW)andterahertz(THz)wesbasedonphotonics–basedtechniques.Uni–treling–photodiode(UTC–PD)isanexcellentcandidate,notonlymeetingtheabove–mentionedrequirementsofbroadband(3GHz~1THz)andhigh–frequencyoperation,butalsoexhibitingthehighoutputpowerovermW–levelatthe300GHzband.Thispaperreviewsthefundamentalsofhigh–speed,high–powerphotodiodes,mirror–reflectedphotodiodes,microstructurephotodiodes,photodiode–integrateddevices,therelatedequivalentcircuits,anddesignconsiderations.Thosecharacteristicsofphotodiodesandtherelatedphotonic–baseddevicesareanalyzedandreviewedwithcomparisonsindetail,whichprovidesanewpathforthesedeviceswithapplicationsinshort–rangewirelesscommunicationsin6Gandbeyond.Fullarticle(ThisarticlebelongstotheSpecialIssueAdvancedOptical-Fiber-RelatedTechnologies)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10---Figure11---Figure12---Figure13---Figure14---Figure15---Figure16---Figure17---Figure18---Figure19---Figure20---Figure21---Figure22---Figure23---Figure24---Figure25---Figure26---Figure27---Figure28---Figure2918pes,4660KiB OpenAccessArticleHurricaneIanDameAssessmentUsingAerialImeryandLiDAR:ACaseStudyofEsteroIsland,FloridabyLeanneHauptman,DianaMitsovaandTiffanyRobertsBriggsJ.Mar.Sci.Eng.2024,12(4),668;doi.org/10.3390/jmse(registering DOI)-17Apr2024AbstractRemotesensingtechniquesheemergedasanessentialtoolforconductingdameassessmentsandarecommonlyusedtoimprovedisasterrecoveryplanningandcommunityresiliencepolicies.TheobjectiveofthisstudywastouseaerialimerydataandLiDARtoidentifythehardest[...]Readmore.Remotesensingtechniquesheemergedasanessentialtoolforconductingdameassessmentsandarecommonlyusedtoimprovedisasterrecoveryplanningandcommunityresiliencepolicies.TheobjectiveofthisstudywastouseaerialimerydataandLiDARtoidentifythehardesthitareas,quantifytheextentofdames,andcomparepre-andpost-stormbeachmorphologyconditionsinEsteroIsland,Florida,relatingtoHurricaneIanin2022.Thisstudyidentified>2400structuresthatwereimpactedbyHurricaneIan,with170structuressufferingextensivedame.Clusteringofheilydamedbuildingswasobservedonthenorthernandcentralportionsoftheisland,withlowerlevelsofdameclusteredonthesouthernpart.Amongthe‘severelydamed’and‘destroyed’structuresweresevenmobilehomesubdivisions.ThetotalassessedvalueoftheheilydamedstructureswasestimatedatoverUSD200million.Theresultsalsoindicatedsubstantialpost-stormdebrisandsanddepositionacrosstheentireisland.Remotesensingprovidesadvancedtechniquesthatcanhelpprioritizeemergencyresponseeffortsaftercatastrophicimpactsfromanaturaldisaster.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10attachmentSupplementarymaterial:SupplementaryFile1(ZIP,101KiB)11pes,460KiB OpenAccessArticleInjectionSiteMatters:AComparativeAnalysisofTranspulmonaryThermodilutionviaSimultaneousFemoralandJugularIndicatorInjectionsunderVeno-VenousExtracorporealMembraneOxygenationTherapybySabrinaKopp,JohannesWindschmitt,LenaSchnauder,ThomasMünzel,KarstenKeller,SusanneKarbach,LukasHobohm,PhilippLurz,IngoSoschenandJohannesWildJ.Clin.Med.2024,13(8),2334;doi.org/10.3390/jcm(registering DOI)-17Apr2024AbstractBackground:Theuseofveno-venousextracorporealmembraneoxygenation(vv-ECMO)inacutelungfailurehaswitnessedanotableincrease.ThePiCCOsystemisfrequentlyusedforadvancedhemodynamicmonitoringinthiscohort.Ourstudyaimedtoinvestigatewhetherthechoiceofindicatorinjection[...]Readmore.Background:Theuseofveno-venousextracorporealmembraneoxygenation(vv-ECMO)inacutelungfailurehaswitnessedanotableincrease.ThePiCCOsystemisfrequentlyusedforadvancedhemodynamicmonitoringinthiscohort.Ourstudyaimedtoinvestigatewhetherthechoiceofindicatorinjectionsite(jugularvs.femoral)inpatientsundergoingvv-ECMOtherapyaffectstranspulmonarythermodilution(TPTD)measurementsusingthePiCCO®device(PulsionMedicalSystemsSE,Munich,Germany).Methods:Inaretrospectivesingle-centeranalysis,wecomparedthermodilution-derivedhemodynamicparametersaftersimultaneousjugularandfemoralinjectionsin28measurementsobtainedintwopatientswithrespiratoryfailurewhowereundergoingvv-ECMOtherapy.Results:Elevatedvaluesoftheextrascularlungwaterindex(EVLWI),intrathoracicbloodvolumeindex(ITBVI)andglobalend-diastolicvolumeindex(GEDVI)wereobservedfollowingfemoralindicatorinjectioncomparedtojugularindicatorinjection(EVLWI:29.3±10.9mL/kgvs.18.3±6.71mL/kg,p=0.0003;ITBVI:2163±631mL/m2vs.806±125mL/m2,p<0.0001;GEDVI:1731±505mL/m2vs.687±141mL/m2,p<0.0001).Thediscrepancybetweenfemoralandjugularmeasurementsexhibitedalinearcorrelationwithextracorporealbloodflow(ECBF).Conclusions:InaPiCCO®-derivedhemodynamicassessmentofpatientsonvv-ECMO,thefemoralindicatorinjection,asopposedtothejugularinjection,resultedinanoverestimationofallindexparameters.Thisdiscrepancycanbeattributedtomeantransittime(MTt)anddownslopetime-dependent(DSt)variationsinGEDVIandcardiacfunctionindexandiscorrelatedwithECBF.Fullarticle(ThisarticlebelongstotheSpecialIssueRiskFactorsandOutcomesofExtracorporealMembraneOxygenation(ECMO))attachmentSupplementarymaterial:SupplementaryFile1(ZIP,125KiB)14pes,2319KiB OpenAccessArticleDrinkingBehiourofBeefCattleSubjecttoWaterMedicationinVariousEnvironmentalConditionsbyEliéderPratesRomanzini,VivienneMcCollum,SarahMcilveen,KawaneDiasdaSilva,WilliamLuizdeSouza,PriscilaArrigucciBernardesandDiogoFleuryAzevedoCostaRuminants2024,4(2),213-226;doi.org/10.3390/ruminants-17Apr2024AbstractTwoexperimentswereconductedtoassesstheeffectsofwatermedicationtechnologyonbeefcattlebehiourandperformanceintropicalconditions.Experiment1involved30Droughtmasteryearlingsteersmonitoredoversevendaysinacontrolledenvironment.Feedandwaterconsumptionsweremonitoredwith[...]Readmore.Twoexperimentswereconductedtoassesstheeffectsofwatermedicationtechnologyonbeefcattlebehiourandperformanceintropicalconditions.Experiment1involved30Droughtmasteryearlingsteersmonitoredoversevendaysinacontrolledenvironment.FeedandwaterconsumptionsweremonitoredwithSmartFeedPro®systems,withthreewatertreatmentsadministeredviauDOSE®technology.Theresultsindicatedanerewaterintakeof13.6L/head/d.Experiment2had120yearlingsteersfromfourgeneticgroupsgrazingonanextensivepasturesystem.Throughoutfour24-dayperiods,foreailabilityandchemicalcompositionweremeasuredoncemonthly.Experiment2revealedavariationinwaterintake,rangingfrom16.2L/head/ddownto4.75L/head/d.Notably,thelowerintakecoincidedwitharainfalleventdocumentedduringthefourthexperimentalperiod.Overall,resultsfrombothexperimentsindicatedthatwatermedicationdidnotaltercattlewaterpreference.TherewasnopreferencefortreatedwatersourcesinExperiment1,whiledifferencesinExperiment2appearedtobeinfluencedbyexternalfactorslikeweatherandpriorhabits.Theseexperimentsdemonstratethefeasibilityofwatermedicationforbeefcattlewithoutdisruptionoftheirnaturalbehiour.Fullarticle(ThisarticlebelongstotheSpecialIssueBeefCattleProductionandManement)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure710pes,1591KiB OpenAccessCommunicationFrequencyofGenePolymorphismsinAdmixedVenezuelanWomenwithRecurrentPregnancyLoss:MicrosomalEpoxyHydroxylase(rs)andEnos(rs)byMaríaJohannaPeña,ClaudiaValentinaDeSanctis,JuanBautistaDeSanctisandJennyValentinaGarmendiaCurr.IssuesMol.Biol.2024,46(4),3460-3469;doi.org/10.3390/cimb-17Apr2024AbstractRecurrentpregnancyloss(RPL)affectsaround2%ofwomenofreproductivee.PrimaryRPLisdefinedby≥2pregnancylossesandnonormalbirthdelivery.InsecondaryRPL,thelossesareafteranormalpregnancyanddelivery.Mostcaseshenoclearaetiology,[...]Readmore.Recurrentpregnancyloss(RPL)affectsaround2%ofwomenofreproductivee.PrimaryRPLisdefinedby≥2pregnancylossesandnonormalbirthdelivery.InsecondaryRPL,thelossesareafteranormalpregnancyanddelivery.Mostcaseshenoclearaetiology,althoughprimarycasesarethemostcomplex.Severalgenesinglenucleotidepolymorphisms(SNPs)hebeenassociatedwithRPL.ThefrequencyofsomeSNPsisincreasedinwomensufferingfromRLPfromAsianorCaucasianraces;however,inadmixedpopulations,theinformationonpossiblegeneticlinksisscarceandcontradictory.ThisstudyaimedtoassessthefrequencyoftwoSNPspresentintwodifferentenzymesinvolvedinmedicalconditionsobservedduringpregnancy.Itisacase–controlstudy.Microsomalepoxyhydrolase(mEPH)isinvolvedindetoxifyingxenobiotics,ispresentintheovaries,andishormonallyregulated.Theendothelialnitricoxidesynthase(NOS3)thatformsnitricisinvolvedinvasculartone.TwoSNPs,rs(mEPH)andrs(NOS3),wereassessed.Thestudyincluded50controlsand63primaryRPLpatients.ThefrequencyofmutatedallelesinbothSNPswassignificantlyhigherinpatients(p<0.05).Double-mutatedhomozygoteswereencounteredonlyinRPLpatients(p<0.05).GeneticpolymorphismsrsandrsmaybeinvolvedinprimaryRPLintheVenezuelanadmixpopulation.GeneticstudiescouldprovidecrucialinformationontheaetiologyofprimaryRPL.Fullarticle(ThisarticlebelongstotheSpecialIssueMolecularResearchinReproductiveBiology,2ndEdition)9658;9660;ShowFiguresFigure122pes,8453KiB OpenAccessArticleMicroRNAsinthePathogenesisofPreeclampsia—ACase-ControlInSilicoAnalysisbyRamanathanKasimanickamandVanmathyKasimanickamCurr.IssuesMol.Biol.2024,46(4),3438-3459;doi.org/10.3390/cimb-17Apकृपया प्रतीक्षा करें... बादल फ्लेरr2024AbstractPreeclampsia(PE)occursin5%to7%ofallpregnancies,andthePEthatresultsfromabnormalplacentationactsasaprimarycauseofmaternalandneonatalmorbidityandmortality.TheobjectiveofthissecondaryanalysiswastoelucidatethepathogenesisofPE[...]Readmore.Preeclampsia(PE)occursin5%to7%ofallpregnancies,andthePEthatresultsfromabnormalplacentationactsasaprimarycauseofmaternalandneonatalmorbidityandmortality.TheobjectiveofthissecondaryanalysiswastoelucidatethepathogenesisofPEbyprobingprotein–proteininteractionsfrominsilicoanalysisoftranscriptomesbetweenPEandnormalplacentafromGeneExpressionOmnibus(GSE).ThepathogenesisofPEisapparentlydeterminedbyassociationsofmiRNAmoleculesandtheirtargetgenesandthedegreeofchangesintheirexpressionswithirregularitiesinthefunctionsofhemostasis,vascularsystems,andinflammatoryprocessesatthefetal–maternalinterface.Theseirregularitiesultimatelyleadtoimpairedplacentalgrowthandhypoxicinjuries,generallymanifestingasplacentalinsufficiency.ThesedifferentiallyexpressedmiRNAsorgenesinplacentaltissueand/orinbloodcanserveasnoveldinosticandtherapeuticbiomarkers.Fullarticle(ThisarticlebelongstotheSectionBioinformaticsandSystemsBiology)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure1012pes,254KiB OpenAccessArticleThePsychosocialHealthofBlack/AfricanAmericansComparedwithPeopleofOtherRaces/EthnicOriginsduringtheCOVID-19PandemicbyDaiciaPrice,ToreBonsaksen,JanniLeung,MaryRuffolo,GaryLamph,KarisHawkinsandAmyØstertunGeirdalCOVID2024,4(4),506-517;doi.org/10.3390/covid-17Apr2024AbstractThisstudycomparedthepsychosocialhealthbetweenBlack/AfricanAmericansandotherethnicgroupsduringtheCOVID-19pandemic.Usingself-reportquestionnaires,datawerecollectedatthreetimepointsfromApril2020toJanuary2022,controllingforeducationandemploymentstatus.Surprisingly,Black/AfricanAmericanparticipants[...]Readmore.ThisstudycomparedthepsychosocialhealthbetweenBlack/AfricanAmericansandotherethnicgroupsduringtheCOVID-19pandemic.Usingself-reportquestionnaires,datawerecollectedatthreetimepointsfromApril2020toJanuary2022,controllingforeducationandemploymentstatus.Surprisingly,Black/AfricanAmericanparticipantsconsistentlyreportedlowerpsychologicaldistresscomparedtotheircounterparts.However,theyinitiallyreportedlowerqualityoflife,whichimprovedovertime,eventuallysurpassingthatoftheothergroupsbyJanuary2022.ThesefindingssuggestresilienceamongBlack/AfricanAmericansdespitehistoricalmarginalization.Socioeconomicfactorsandhistoricalcontextmayheinfluencedthesedisparities,highlightingtheneedfortargetedinterventionstosupportmarginalizedcommunitiesduringcrises.Fullarticle35pes,KiB OpenAccessReviewUncommonCausesofInterlobularSeptalThickeningonCTImesandTheirDistinguishingFeaturesbyAchalaDonuru,DrewA.TorigianandFriedrichKnollmannTomography2024,10(4),574-608;doi.org/10.3390/tomography-17Apr2024AbstractInterlobularseptathickening(ILST)isacommonandeasilyrecognizedfeatureoncomputedtomography(CT)imesinmanylungdisorders.ILSTthickeningcanbesmooth(mostcommon),nodular,orirregular.SmoothILSTcanbeseeninpulmonaryedema,pulmonaryalveolarproteinosis,andlymphangitic[...]Readmore.Interlobularseptathickening(ILST)isacommonandeasilyrecognizedfeatureoncomputedtomography(CT)imesinmanylungdisorders.ILSTthickeningcanbesmooth(mostcommon),nodular,orirregular.SmoothILSTcanbeseeninpulmonaryedema,pulmonaryalveolarproteinosis,andlymphangiticspreadoftumors.NodularILSTcanbeseeninthelymphangiticspreadoftumors,sarcoidosis,andsilicosis.IrregularILSTisafindingsuggestiveofinterstitialfibrosis,whichisacommonfindinginfibroticlungdiseases,includingsarcoidosisandusualinterstitialpneumonia.PulmonaryedemaandlymphangiticspreadoftumorsarethecommonlyencounteredcausesofILST.ItisimportanttonarrowdownthedifferentialdinosisasmuchaspossiblebyassessingtheappearanceanddistributionofILST,aswellasotherpulmonaryandextrapulmonaryfindings.ThisreviewwillfocusontheCTcharacterizationofthesecondarypulmonarylobuleandILST.VariousuncommoncausesofILSTwillbediscussed,includinginfections,interstitialpneumonia,depositional/infiltrativeconditions,inhalationaldisorders,malignancies,congenital/inheritedconditions,andiatrogeniccauses.AwarenessoftheimingappearanceandvariouscausesofILSTallowsforasystematicapproach,whichisimportantforatimelydinosis.ThisstudyhighlightstheimportanceofastructuredapproachtoCTscananalysisthatconsidersILSTcharacteristics,associatedfindings,anddifferentialdinosticconsiderationstofacilitateaccuratedinoses.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10---Figure10Cont.---Figure11---Figure12---Figure13---Figure14---Figure15---Figure16---Figure17---Figure18---Figure19---Figure19Cont.---Figure20---Figure21---Figure22---Figure23---Figure24---Figure24Cont.MoreArticles...OpenAccessJournalsAcousticsActaMicrobiologicaHellenica(AMH)ActuatorsAdministrativeSciencesAdolescentsAdvancesinRespiratoryMedicine(ARM)AerobiologyAerospacericultureriEngineeringrochemicalsronomyAIAirAlgorithmsAllergiesAlloysAnalyticaAnalyticsAnatomiaAnesthesiaResearchAnimalsAntibioticsAntibodiesAntioxidantsAppliedBiosciencesAppliedMechanicsAppliedMicrobiologyAppliedNanoAppliedSciencesAppliedSystemInnovation(ASI)AppliedChemAppliedMathAquacultureJournalArchitectureArthropodaArtsAstronomyAtmosphereAtomsAudiologyResearchAutomationAxiomsBacteriaBatteriesBehioralSciencesBeveresBigDataandCognitiveComputing(BDCC)BioChemBioengineeringBiologicsBiologyBiologyandLifeSciencesForumBiomassBiomechanicsBioMedBiomedicinesBioMedInformaticsBiomimeticsBiomoleculesBiophysicaBiosensorsBioTechBirdsBlockchainsBrainSciencesBuildingsBusinessesCCancersCardiogeneticsCatalystsCellsCeramicsChallengesChemEngineeringChemistryChemistryProceedingsChemosensorsChildrenChipsCivilEngCleanTechnologies(CleanTechnol.)ClimateClinicalandTranslationalNeuroscience(CTN)ClinicsandPracticeClocks&SleepCoastsCoatingsColloidsandInterfacesColorantsCommoditiesComplicationsCompoundsComputationComputerSciences&MathematicsForumComputersCondensedMatterConservationConstructionMaterialsCorrosionandMaterialsDegradation(CMD)CosmeticsCOVIDCropsCryptographyCrystalsCurrentIssuesinMolecularBiology(CIMB)CurrentOncologyDairyDataDentistryJournalDermatoDermatopathologyDesignsDiabetologyDinosticsDieteticsDigitalDisabilitiesDiseasesDiversityDNADronesDrugsandDrugCandidates(DDC)DynamicsEarthEcologiesEconometricsEconomiesEducationSciencesElectricityElectrochemElectronicMaterialsElectronicsEmergencyCareandMedicineEncyclopediaEndocrinesEnergiesEngEngineeringProceedingsEntropyEnvironmentalSciencesProceedingsEnvironmentsEpidemiologiaEpigenomesEuropeanBurnJournal(EBJ)EuropeanJournalofInvestigationinHealth,PsychologyandEducation(EJIHPE)FermentationFibersFinTechFireFishesFluidsFoodsForecastingForensicSciencesForestsFossilStudiesFoundationsFractalandFractional(FractalFract)FuelsFutureFutureInternetFuturePharmacologyFutureTransportationGalaxiesGamesGasesGastroenterologyInsightsGastrointestinalDisordersGastronomyGelsGenealogyGenesGeographiesGeoHazardsGeomaticsGeosciencesGeotechnicsGeriatricsGlaciesGout,Urate,andCrystalDepositionDisease(GUCDD)GrassesHardwareHealthcareHeartsHematoHematologyReportsHeriteHistoriesHorticulturaeHospitalsHumanitiesHumansHydrobiologyHydrogenHydrologyHygieneImmunoInfectiousDiseaseReportsInformaticsInformationInfrastructuresInorganicsInsectsInstrumentsInternationalJournalofEnvironmentalResearchandPublicHealth(IJERPH)InternationalJournalofFinancialStudies(IJFS)InternationalJournalofMolecularSciences(IJMS)InternationalJournalofNeonatalScreening(IJNS)InternationalJournalofPlantBiology(IJPB)InternationalJournalofTopologyInternationalJournalofTranslationalMedic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